Predicted endpoints

This is the predicted enpoint table for model Rat toxicity prediction with Ensemble of Classifier Chains.

endpointdescription#active#inactive#missingactiveinactivesub-accutesub-chronic
liver-weight-increasedSignificant adverse increase in relative and/or absolute liver weight292225505sub-accute <= 1.63, sub-chronic <= 0.79sub-accute >= 1.67, sub-chronic >= 0.84
body-weight-decreasedSignificant decrease in body weight202214606sub-accute <= 1.91, sub-chronic <= 0.94sub-accute >= 1.98, sub-chronic >= 0.97
liverSignificant adverse changes in liver, including atrophy, fatty degeneration, lipidosis, mineralization, necrosis, polynuclear cells, vacuolization, hypertrophic changes, and histopathological changes related to inflammation and/or regeneration like cirrhosis, eosinophilic structures, fibrosis, granulocytes, granuloma, infiltration, inflammation, lymphocytes, macrophages, regenerative changes, swelling259146617sub-accute <= 1.76, sub-chronic <= 0.88sub-accute >= 1.83, sub-chronic >= 0.92
kidney-weight-increasedSignificant adverse increase in relative and/or absolute kidney weight169160693sub-accute <= 1.74, sub-chronic <= 0.86sub-accute >= 1.76, sub-chronic >= 0.89
cnsSignificant adverse clinical symptoms related to effects on the central nervous system171151700sub-accute <= 1.56, sub-chronic <= 0.79sub-accute >= 1.67, sub-chronic >= 0.81
rbcSignificant adverse changes in red blood cells, including erythrocytes, haematocrit and haemoglobin160155707sub-accute <= 1.51, sub-chronic <= 0.77sub-accute >= 1.63, sub-chronic >= 0.8
kidneySignificant adverse histopathological changes and/or decrease in absolute or relative weight observed in kidney including histopathological changes related to degeneration, inflammation, and regeneration163118741sub-accute <= 1.71, sub-chronic <= 0.8sub-accute >= 1.74, sub-chronic >= 0.89
clinchem-nephrotoxSignificant adverse changes in clinical chemistry related to kidney toxicity: creatinine, urea/nitrogen98122802sub-accute <= 1.51, sub-chronic <= 0.7sub-accute >= 1.56, sub-chronic >= 0.77
spleenSignificant adverse histopathological changes and/or changes in absolute or relative weight observed in spleen109105808sub-accute <= 1.49, sub-chronic <= 0.79sub-accute >= 1.67, sub-chronic >= 0.83
wbcSignificant adverse changes in white blood cell count11895809sub-accute <= 1.85, sub-chronic <= 0.92sub-accute >= 1.93, sub-chronic >= 0.95
haematology-anaemiaAnaemia, significant7266884sub-accute <= 1.43, sub-chronic <= 0.7sub-accute >= 1.67, sub-chronic >= 0.82
haematology-cellular-hemostasisSignificant adverse effects related to cellular hemostasis5356913sub-accute <= 1.57, sub-chronic <= 0.77sub-accute >= 1.67, sub-chronic >= 0.86
female-reproductive-organSignificant adverse histopathological changes and/or changes in absolute or relative weight observed in female reproductive organs: uterus, ovaries, vagina, clitoral gland, cylcle length4859915sub-accute <= 1.79, sub-chronic <= 0.89sub-accute >= 1.93, sub-chronic >= 1.01
adrenal-gland-weight-increasedSignificant relative and/or absolut weight of adrenal gland increased4459919sub-accute <= 1.49, sub-chronic <= 0.29sub-accute >= 1.56, sub-chronic >= 0.83
brainSignificant adverse histopathological changes and/or changes in absolute weight observed in brain3363926sub-accute <= 1.16, sub-chronic <= 0.77sub-accute >= 1.67, sub-chronic >= 0.83
clinchem-hepatotoxSignificant adverse changes in clinical chemistry related to liver toxicity: decreased cholesterol, decreased Aspartate aminotransferase4942931sub-accute <= 1.82, sub-chronic <= 0.71sub-accute >= 1.96, sub-chronic >= 1.06
thymus-weight-decreasedSignificant adverse decrease in thymus weight3652934sub-accute <= 1.4, sub-chronic <= 0.56sub-accute >= 1.63, sub-chronic >= 0.83
haematology-plasmatic-hemostasisSignificant adverse effects related to plasmatic hemostasis4633943sub-accute <= 1.68, sub-chronic <= 0.8sub-accute >= 1.82, sub-chronic >= 1.41
male-reproductive-organSignificant adverse changes in male reproductive organ3543944sub-accute <= 1.47, sub-chronic <= 0.76sub-accute >= 1.63, sub-chronic >= 0.82
haematopoiesisSignificant adverse effects on haematopoesis4631945sub-accute <= 1.35, sub-chronic <= 0.65sub-accute >= 1.67, sub-chronic >= 0.83
intestineSignificant adverse histopathological changes and/or changes in absolute or relative weight observed in intestine4429949sub-accute <= 1.83, sub-chronic <= 0.86sub-accute >= 2.07, sub-chronic >= 1
male-reproductive-organ-weight-increasedSignificant adverse increase in absolute weight of male reproductive organs: epididymis, testes2344955sub-accute <= 1.35, sub-chronic <= 0.71sub-accute >= 1.68, sub-chronic >= 0.88
thyroid-glandSignificant adverse changes in histopathology or weight of thyroid gland4720955sub-accute <= 1.63, sub-chronic <= 0.86sub-accute >= 2.31, sub-chronic >= 0.97
male-reproductive-organ-spermSignificant adverse changes in sperm parameters2536961sub-accute <= 1.21, sub-chronic <= 0.71sub-accute >= 1.79, sub-chronic >= 0.82
male-reproductive-organ-weight-decreasedSignificant adverse decrease in absolute weight of male reproductive organs: epididymis, testes2437961sub-accute <= 1.82, sub-chronic <= 0.76sub-accute >= 2.17, sub-chronic >= 0.99
thymusSignificant adverse changes in thymus histopathology related to degeneration: atrophy, cell depletion, degeneration, necrosis2039963sub-accute <= 1.43, sub-chronic <= 0.18sub-accute >= 1.71, sub-chronic >= 0.88
bone-marrowSignificant adverse histopathological changes observed in bone marrow1925978sub-accute <= 0.82, sub-chronic <= 0.67sub-accute >= 1.79, sub-chronic >= 0.92
male-accessory-glandSignificant adverse histopathological or weight changes in male accessory glands: preputial gland, prostate, seminal vesicle1727978sub-accute <= 1.79, sub-chronic <= 0.81sub-accute >= 2.01, sub-chronic >= 1.01