Predicted endpoints

This is the predicted enpoint table for model Rat toxicity prediction with Predictive Clustering Trees.

endpointdescription#active#inactive#missing
adrenal-gland-weight-increasedSignificant relative and/or absolut weight of adrenal gland increased4254803
body-weight-decreasedSignificant decrease in body weight186175538
bone-marrowSignificant adverse histopathological changes observed in bone marrow1825856
brainSignificant adverse histopathological changes and/or changes in absolute weight observed in brain3261806
clinchem-hepatotoxSignificant adverse changes in clinical chemistry related to liver toxicity: decreased cholesterol, decreased Aspartate aminotransferase4941809
clinchem-nephrotoxSignificant adverse changes in clinical chemistry related to kidney toxicity: creatinine, urea/nitrogen93117689
cnsSignificant adverse clinical symptoms related to effects on the central nervous system164144591
female-reproductive-organSignificant adverse histopathological changes and/or changes in absolute or relative weight observed in female reproductive organs: uterus, ovaries, vagina, clitoral gland, cylcle length4759793
haematology-anaemiaAnaemia, significant7065764
haematology-cellular-hemostasisSignificant adverse effects related to cellular hemostasis5154794
haematology-plasmatic-hemostasisSignificant adverse effects related to plasmatic hemostasis4433822
haematopoiesisSignificant adverse effects on haematopoesis4431824
intestineSignificant adverse histopathological changes and/or changes in absolute or relative weight observed in intestine4328828
kidneySignificant adverse histopathological changes and/or decrease in absolute or relative weight observed in kidney including histopathological changes related to degeneration, inflammation, and regeneration157110632
kidney-weight-increasedSignificant adverse increase in relative and/or absolute kidney weight159142598
liverSignificant adverse changes in liver, including atrophy, fatty degeneration, lipidosis, mineralization, necrosis, polynuclear cells, vacuolization, hypertrophic changes, and histopathological changes related to inflammation and/or regeneration like cirrhosis, eosinophilic structures, fibrosis, granulocytes, granuloma, infiltration, inflammation, lymphocytes, macrophages, regenerative changes, swelling252138509
liver-weight-increasedSignificant adverse increase in relative and/or absolute liver weight272207420
male-accessory-glandSignificant adverse histopathological or weight changes in male accessory glands: preputial gland, prostate, seminal vesicle1626857
male-reproductive-organSignificant adverse changes in male reproductive organ3242825
male-reproductive-organ-spermSignificant adverse changes in sperm parameters2334842
male-reproductive-organ-weight-decreasedSignificant adverse decrease in absolute weight of male reproductive organs: epididymis, testes2234843
male-reproductive-organ-weight-increasedSignificant adverse increase in absolute weight of male reproductive organs: epididymis, testes2243834
rbcSignificant adverse changes in red blood cells, including erythrocytes, haematocrit and haemoglobin150149600
spleenSignificant adverse histopathological changes and/or changes in absolute or relative weight observed in spleen105103691
thymusSignificant adverse changes in thymus histopathology related to degeneration: atrophy, cell depletion, degeneration, necrosis1939841
thymus-weight-decreasedSignificant adverse decrease in thymus weight3649814
thyroid-glandSignificant adverse changes in histopathology or weight of thyroid gland4518836
wbcSignificant adverse changes in white blood cell count11390696